Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 质控信息
Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 生物活性
描述
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, pH 8.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 技术信息
CAS号
N/A
分子量
61.5 KDa
SMILES Code
NONE
别名
重组人SMAD4蛋白(C-6His, E.coli)
;Recombinant Human SMAD4 (C-6His, E.coli); Mothers Against Decapentaplegic Homolog 4; MAD Homolog 4; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; SMAD Family Member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DPC4; MADH4
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli)
|Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli)
| 重组人SMAD4蛋白(C-6His, E.coli)
| Recombinant Human SMAD4 (C-6His, E.coli)
| Mothers Against Decapentaplegic Homolog 4
| MAD Homolog 4
| Mothers Against DPP Homolog 4
| Deletion Target in Pancreatic Carcinoma 4
| SMAD Family Member 4
| SMAD 4
| Smad4
| hSMAD4
| SMAD4
| DPC4
| MADH4
| N/A
| TGF-beta Superfamily
| Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 纯度/质量文件
| Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 生物活性
| Human SMAD4 (C-6His, E.coli)/人SMAD4蛋白(C-6His, E.coli) 技术信息
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