Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. Receptor tyrosine kinase like orphan receptor (ROR) family of proteins belongs to the noncanonical wingless-related integration site (Wnt) signaling pathway, closely related to MuSK (muscle-specific kinase) and Trk (tropomyosin) family receptors. The extracellular region (ectodomain) contains an immunoglobulin-like domain (IgG), a cysteine-rich domain (CRD) with sequence and structural similarities to the CRD of Frizzled proteins followed by a Kringle domain. A single transmembrane helix connects the ectodomain to the cytoplasmic region, which contains a tyrosine kinase-like or pseudokinase domain followed by two serine/threonine (Ser/Thr) rich domains flanking a proline (Pro)-rich domain. A combination therapy with ROR1- and BCR-targeted agents for ROR1-positive B-cell malignancies will probably be clinically advantageous.
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4
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Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 1 个月。
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