Recombinant Human ROR1 (C-Fc, HEK293)是人类ROR1蛋白，在HEK293人源细胞中表达，带有C端Fc标签。该蛋白属于ROR酪氨酸激酶家族，是一种I型跨膜蛋白，全长937个氨基酸，包含信号肽、胞外域、跨膜区及胞内区，与小鼠ROR1同源性为97%。ROR1可能作为WNT5A受体，调节WNT信号通路，主要在心脏、肺和肾脏中高表达，其短异构体在神经系统和多种癌症中富集。
Human ROR1 (C-Fc, HEK293)/人ROR1蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human ROR1 (C-Fc, HEK293)/人ROR1蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human ROR1 (C-Fc, HEK293)/人ROR1蛋白(C-Fc, HEK293) 质控信息
Human ROR1 (C-Fc, HEK293)/人ROR1蛋白(C-Fc, HEK293) 生物活性
描述
ROR1，also known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family,a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97% and 58% aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human ROR1 (C-Fc, HEK293)/人ROR1蛋白(C-Fc, HEK293) 技术信息
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