Recombinant Human PTH (N-8His, HEK293)是人类甲状旁腺激素（PTH）重组蛋白，由人源细胞表达，带有N端8个组氨酸标签。该蛋白是调节钙磷平衡的关键激素，主要由甲状旁腺分泌，作用于骨骼与肾脏，促进维生素D活化，减少尿钙排泄并增加磷酸盐排出，同时可刺激造血干细胞增殖、动员，并通过调控钙离子内流引发动脉血管舒张。
Human PTH (N-8His, HEK293)/人PTH蛋白(N-8His, HEK293) 化学结构 CAS号：N/A
Human PTH (N-8His, HEK293)/人PTH蛋白(N-8His, HEK293) 3D分子结构 CAS号：N/A
Human PTH (N-8His, HEK293)/人PTH蛋白(N-8His, HEK293) 质控信息
Human PTH (N-8His, HEK293)/人PTH蛋白(N-8His, HEK293) 生物活性
描述
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone. After intracellular processing, the mature hormone is packaged with in the Golgi into secretory vesicles, the secreted into blood by exocytosis. In renal epithelium, PTH promotes conversion of Vitamin D to its active form, lowers Ca++ excretion and increases phosphate excretion. PTH also increases hematopoietic stem cell proliferation and mobilization and induces arterial vasodilation by regulating Ca++ influx in PTH1R-expressing arterial smooth muscle.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human PTH (N-8His, HEK293)/人PTH蛋白(N-8His, HEK293) 技术信息
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