货号:A2925948
同义名:
重组人PTGDS蛋白(C-6His, HEK293)
/ Recombinant Human PTGDS (C-6His, HEK293); Prostaglandin-H2 D-Isomerase
Recombinant Human PTGDS (C-6His, HEK293) 是人源Prostaglandin-H2 D-Isomerase蛋白,在人源细胞中表达,带有C端6×His标签。该蛋白属于Lipocalin家族,主要在脑中表达,催化PGH2转化为具有平滑肌收缩/舒张调节及抗血小板聚集作用的PGD2,参与中枢神经系统的多种功能,并可能发挥抗凋亡作用,还能结合脂溶性小分子,参与多种生理屏障的形成与维护。


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| 描述 | Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions, such as sedation, REM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor, blood-testis barrier, the central nervous system and male reproductive system. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Ala23-Gln190 |
| 蛋白编号 | P41222 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 19.7 KDa |
| SMILES Code | NONE |
| 别名 | 重组人PTGDS蛋白(C-6His, HEK293) ;Recombinant Human PTGDS (C-6His, HEK293); Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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