Recombinant Human PSMA (N-6His, HEK293)是人类来源的蛋白，在HEK293人源细胞中表达，带有N端6His标签。该蛋白又称谷氨酸羧肽酶2或FOLH1，属于M28B亚家族及肽酶M28家族，高表达于前列腺上皮，并在多个组织中低水平检出，与前列腺癌诊断预后及多种神经疾病相关，具有叶酸水解酶和NAALADase活性，可切割三谷氨酸肽，且在pH大于6.5时稳定。
Human PSMA (N-6His, HEK293)/人PSMA蛋白(N-6His, HEK293) 化学结构 CAS号：N/A
Human PSMA (N-6His, HEK293)/人PSMA蛋白(N-6His, HEK293) 3D分子结构 CAS号：N/A
Human PSMA (N-6His, HEK293)/人PSMA蛋白(N-6His, HEK293) 质控信息
Human PSMA (N-6His, HEK293)/人PSMA蛋白(N-6His, HEK293) 生物活性
描述
Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.
搜索
