Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His)
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货号：A2900834同义名：
重组人PD-1蛋白(HEK293, C-6His)
/ Recombinant Human PD-1 (C-6His); Programmed cell death protein 1
Recombinant Human PD-1 (C-6His) 是人源程序性死亡蛋白1，在人源细胞中表达，带有C端6×His标签。该蛋白是一种单次跨膜I型膜蛋白，属于CD28/CTLA-4家族T细胞调节因子，可通过抑制PI3K/AKT通路及BCR信号传导，调控T细胞增殖与细胞因子分泌，参与淋巴细胞克隆选择和外周耐受，从而调节适应性免疫应答并预防自身免疫疾病。
Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 化学结构 CAS号：N/A
Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 3D分子结构 CAS号：N/A
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 技术信息
CAS号
N/A
分子量
16.8 KDa
SMILES Code
NONE
别名
重组人PD-1蛋白(HEK293, C-6His)
;Recombinant Human PD-1 (C-6His); Programmed cell death protein 1; PDCD1; PD-1; hPD-1; CD279
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His)
|Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His)
| 重组人PD-1蛋白(HEK293, C-6His)
| Recombinant Human PD-1 (C-6His)
| Programmed cell death protein 1
| PDCD1
| PD-1
| hPD-1
| CD279
| N/A
| Macrophage CD Proteins
| Immune Checkpoint Proteins
| T Cell CD Proteins
| Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 纯度/质量文件
| Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 生物活性
| Human PD-1 (C-6His)/人PD-1蛋白(HEK293, C-6His) 技术信息
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