货号:A2925535
同义名:
重组人Nectin-4蛋白(C-Fc, HEK293)
/ Recombinant Human Nectin-4 (C-Fc, HEK293); PVRL4
Recombinant Human Nectin-4 (C-Fc, HEK293) 是人源 Nectin-4 蛋白,在 HEK293 人源细胞中表达,带有 C-Fc 标签。该蛋白属于 Ig 超家族,具有两个 Ig 样 C2 型结构域和一个 Ig 样 V 型结构域,主要参与细胞间粘附,通过同源及异源相互作用发挥作用,不介导 α-疱疹病毒进入细胞。其高表达于胎盘、胚胎及乳腺癌组织,可经 ADAM17 裂解产生可溶形式,与先天性外胚层发育不良伴并指综合征相关。


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| 描述 | Nectin-4 (PVRL4) is a type I transmembrane glycoprotein which belongs to the nectin family of Ig superfamily proteins. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with nectin-1. It does not act as receptor for alpha-herpesvirus entry into cells. It is predominantly expressed in placenta, the embryo and breast carcinoma. But it is not detected in normal breast epithelium. The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Gly32-Val351 |
| 蛋白编号 | Q96NY8 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 61.2 KDa |
| SMILES Code | NONE |
| 别名 | 重组人Nectin-4蛋白(C-Fc, HEK293) ;Recombinant Human Nectin-4 (C-Fc, HEK293); PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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