货号:A2900825
同义名:
重组人MMP-9蛋白(HEK293, C-6His)
/ Recombinant Human MMP-9 (C-6His); Matrix metalloproteinase-9
Recombinant Human MMP-9 (C-6His)是人类来源的重组蛋白,在人源细胞中表达,带有C端6×His标签。该蛋白即基质金属蛋白酶9(MMP-9),由正常肺泡巨噬细胞和粒细胞产生,可被4-氨基苯汞乙酸酯和佛波酯激活,并在结直肠肿瘤细胞中通过JNK信号通路受ARHGEF4、SPATA13和APC上调,参与生理及病理过程中细胞外基质的降解。


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| 描述 | Matrix metallopeptidase 9 (MMP-9) is an enzyme encoded by the MMP9 gene. This protein, which is produced by normal alveolar macrophages and granulocytes, can be activated by 4-aminophenylmercuric acetate and phorbol ester and up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. MMP-9 is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healing, cell migration, learning and memory, as well as in pathological processes, such as arthritis, intracerebral hemorrhage, and metastasis. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Ala19-Asp707 |
| 蛋白编号 | AAH06093.1 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM Hepes,10% Sucrose,150mM NaCl,0.05% Tween 80,2mM CaCl2,pH8.0. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 77.4 KDa |
| SMILES Code | NONE |
| 别名 | 重组人MMP-9蛋白(HEK293, C-6His) ;Recombinant Human MMP-9 (C-6His); Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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