Recombinant Human MMP-1 (C-6His, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C端6His标签。该蛋白由成纤维细胞、角质形成细胞、内皮细胞、单核细胞和巨噬细胞产生，包含前结构域、催化结构域、铰链区和羧基末端结构域，可降解I、II、III、VII、VIII、X型胶原及多种底物，参与细胞外基质重塑、酶级联、细胞因子调控及细胞表面分子调节。
Human MMP-1 (C-6His, HEK293)/人MMP-1蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human MMP-1 (C-6His, HEK293)/人MMP-1蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human MMP-1 (C-6His, HEK293)/人MMP-1蛋白(C-6His, HEK293) 质控信息
Human MMP-1 (C-6His, HEK293)/人MMP-1蛋白(C-6His, HEK293) 生物活性
描述
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, α1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2, and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. MMP1 may also be involved in enzyme cascades, cytokine regulation and cell surface molecule modulation.
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