Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293)
{[allProObj[0].p_purity_real_show]}
货号：A2925170同义名：
重组人M-CSF R蛋白(C-6His, HEK293)
/ Recombinant Human M-CSF R (C-6His, HEK293); Macrophage colony-stimulating factor 1 receptor
Recombinant Human M-CSF R (C-6His, HEK293) 是人源巨噬细胞集落刺激因子1受体（CSF1R）重组蛋白，在HEK293人源细胞中表达，带有C端6×His标签。该蛋白属于III型受体酪氨酸激酶家族，主要表达于单核/巨噬细胞系、树突细胞及干细胞等，参与调控破骨细胞增殖与分化、骨吸收、生殖功能及乳腺发育，异常表达与多种炎症性疾病相关。
Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293) 质控信息
Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293) 生物活性
描述
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. It plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. It is required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human M-CSF R (C-6His, HEK293)/人M-CSF R蛋白(C-6His, HEK293) 技术信息
搜索
