Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293)
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货号：A2924469同义名：
重组人KNG1蛋白(C-6His, HEK293)
/ Recombinant Human KNG1 (C-6His, HEK293); Kininogen-1
Recombinant Human KNG1 (C-6His, HEK293)是人源KNG1蛋白，在HEK293细胞中表达，带有C端6×His标签。该蛋白是一种分泌型蛋白，包含三个半胱氨酸蛋白酶抑制剂结构域，有高分子量（HMW）和低分子量（LMW）两种剪接形式，参与凝血与炎症反应，可调控前激肽释放酶和凝血因子的定位，并抑制血小板聚集，其活性肽缓激肽具有多种生理效应，包括调节血管通透性、血压及炎症反应，具有心脏保护作用。
Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293) 质控信息
Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293) 生物活性
描述
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.
Lyophilized from a 0.2 μm filtered solution of 20mM Hac-NaAC, 150mM NaCl, pH 4.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human KNG1 (C-6His, HEK293)/人KNG1蛋白(C-6His, HEK293) 技术信息
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