货号:A2925133
同义名:
重组人KIR2DL3蛋白(C-Fc, HEK293)
/ Recombinant Human KIR2DL3 (C-Fc, HEK293); Killer cell immunoglobulin-like receptor 2DL3
Recombinant Human KIR2DL3 (C-Fc, HEK293) 是人源KIR2DL3蛋白,在HEK293细胞中表达,带有C-Fc标签。该蛋白属于杀伤细胞免疫球蛋白样受体家族,是重要的免疫系统分子,主要表达于NK细胞表面,通过与MHC I类分子(如HLA-Cw1、-Cw3、-Cw7和Cw8)相互作用,抑制NK细胞的杀伤活性,从而防止对正常细胞的误伤,是重要的免疫调节因子。


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| 描述 | Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | His22-His245 |
| 蛋白编号 | P43628 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 51.7 KDa |
| SMILES Code | NONE |
| 别名 | 重组人KIR2DL3蛋白(C-Fc, HEK293) ;Recombinant Human KIR2DL3 (C-Fc, HEK293); Killer cell immunoglobulin-like receptor 2DL3; KIR2DL3; CD158b2; NKAT2; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT-2; p58 NK receptor CL-6 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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