Recombinant Human IL-6RA (C-Fc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白为白细胞介素6受体α链（IL6Ra），是IL-6受体的组成部分，与IL-6低亲和力结合但不传递信号，需与IL6ST结合才能激活信号通路，参与免疫调节、急性期反应及造血功能，其可溶性形式可能作为IL-6激动剂，与多发性骨髓瘤、自身免疫疾病及前列腺癌等病理过程相关。
Human IL-6RA (C-Fc, HEK293)/人IL-6RA蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human IL-6RA (C-Fc, HEK293)/人IL-6RA蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human IL-6RA (C-Fc, HEK293)/人IL-6RA蛋白(C-Fc, HEK293) 质控信息
Human IL-6RA (C-Fc, HEK293)/人IL-6RA蛋白(C-Fc, HEK293) 生物活性
描述
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-6RA (C-Fc, HEK293)/人IL-6RA蛋白(C-Fc, HEK293) 技术信息
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