产品名称：Recombinant Human IL-33理论分子量：18.1 KDa蛋白种属：Human表达系统：E.coli蛋白表达区间：Ser112-Thr270标签：Tag free剂型：干粉纯度：≥95% as determined by reducing SDS-PAGE.储存条件：冻干蛋白应储存在≤-20°C，收到后可稳定保存一年。
溶解后的蛋白溶液可以在2-8°C下保存2-7天。如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。产品背景：Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules. It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. Human IL-33 is 270 amino acids in length.
Human IL-33/人IL-33蛋白(E.coli, tag free) 技术信息
CAS号
N/A
分子量
18.1 KDa
SMILES Code
NONE
别名
重组人IL-33蛋白(E.coli, tag free)
;Recombinant Human IL-33
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human IL-33/人IL-33蛋白(E.coli, tag free)
|Human IL-33/人IL-33蛋白(E.coli, tag free)
| 重组人IL-33蛋白(E.coli, tag free)
| Recombinant Human IL-33
| N/A
| Interleukin & Receptors
| Human IL-33/人IL-33蛋白(E.coli, tag free) 纯度/质量文件
| Human IL-33/人IL-33蛋白(E.coli, tag free) 生物活性
| Human IL-33/人IL-33蛋白(E.coli, tag free) 技术信息
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