Human IL-31/人IL-31蛋白(E.coli, tag free)
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货号：A2900795同义名：
重组人IL-31蛋白(E.coli, tag free)
/ Recombinant Human IL-31; Interleukin-31
Recombinant Human IL-31是人白细胞介素31重组蛋白，在大肠杆菌中表达，为无标签蛋白。该蛋白是一种含四螺旋束结构的细胞因子，与IL-6、Oncostatin M等具有结构和功能相似性，主要由活化的Th2细胞表达，通过IL-31RA和OSM Rβ异源二聚体受体传递信号，激活STAT等通路，与皮肤免疫及炎症性疾病相关，可诱导瘙痒和皮炎。
Human IL-31/人IL-31蛋白(E.coli, tag free) 化学结构 CAS号：N/A
Human IL-31/人IL-31蛋白(E.coli, tag free) 3D分子结构 CAS号：N/A
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-31/人IL-31蛋白(E.coli, tag free) 技术信息
CAS号
N/A
分子量
15.8 KDa
SMILES Code
NONE
别名
重组人IL-31蛋白(E.coli, tag free)
;Recombinant Human IL-31; Interleukin-31; IL-31; IL31
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human IL-31/人IL-31蛋白(E.coli, tag free)
|Human IL-31/人IL-31蛋白(E.coli, tag free)
| 重组人IL-31蛋白(E.coli, tag free)
| Recombinant Human IL-31
| Interleukin-31
| IL-31
| IL31
| N/A
| Interleukin & Receptors
| Human IL-31/人IL-31蛋白(E.coli, tag free) 纯度/质量文件
| Human IL-31/人IL-31蛋白(E.coli, tag free) 生物活性
| Human IL-31/人IL-31蛋白(E.coli, tag free) 技术信息
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