Recombinant Human IL-23R (C-Fc, HEK293)是人类白细胞介素23受体（IL23R）重组蛋白，源自人源细胞表达系统，带有C端Fc标签。该蛋白是IL23受体的重组形式，参与IL23信号通路，激活记忆T细胞并介导促炎反应，与多种自身免疫疾病及肿瘤发生密切相关，广泛表达于T细胞、NK细胞、树突细胞和巨噬细胞。
Human IL-23R (C-Fc, HEK293)/人IL-23R蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human IL-23R (C-Fc, HEK293)/人IL-23R蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human IL-23R (C-Fc, HEK293)/人IL-23R蛋白(C-Fc, HEK293) 质控信息
Human IL-23R (C-Fc, HEK293)/人IL-23R蛋白(C-Fc, HEK293) 生物活性
描述
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-23R (C-Fc, HEK293)/人IL-23R蛋白(C-Fc, HEK293) 技术信息
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