货号:A2900787
同义名:
重组人IL-1a蛋白(E.coli, tag free)
/ Recombinant Human IL-1a; Interleukin-1 Alpha
Recombinant Human IL-1a是人源白细胞介素-1α重组蛋白,在大肠杆菌中表达,为无标签形式。该蛋白属于白细胞介素-1家族,主要由上皮细胞组成性产生,对维持皮肤屏障功能至关重要,也能被骨细胞、单核细胞、巨噬细胞等在刺激后诱导表达,具有广泛的代谢、生理、造血活性,参与免疫与炎症反应的调节。


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| 描述 | Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | Tag free |
| 蛋白表达区间 | Ser113-Ala271 |
| 蛋白编号 | P01583 |
| 内毒素 | < 0.01 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 18 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IL-1a蛋白(E.coli, tag free) ;Recombinant Human IL-1a; Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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