Recombinant Human IL-1a (C-Fc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白为白细胞介素-1家族成员IL-1α，主要由上皮细胞组成性产生，对维持皮肤屏障功能至关重要，受刺激后可在多种细胞中诱导表达，具有广泛的代谢、生理及造血活性，参与免疫与炎症反应的调节。
Human IL-1a (C-Fc, HEK293)/人IL-1a蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human IL-1a (C-Fc, HEK293)/人IL-1a蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human IL-1a (C-Fc, HEK293)/人IL-1a蛋白(C-Fc, HEK293) 质控信息
Human IL-1a (C-Fc, HEK293)/人IL-1a蛋白(C-Fc, HEK293) 生物活性
描述
Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-1a (C-Fc, HEK293)/人IL-1a蛋白(C-Fc, HEK293) 技术信息
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