Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 质控信息
Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 生物活性
描述
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma /δ T cells. It associates with the widely expressed IL 17 RA to form a heterodimeric receptor for IL-17C. IL-17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. IL 17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL 17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL 17C with IL 17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL 17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL 17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL 17A, IL 17F, IL 22, CCR6, and CCL20. The up regulation of IL 17 RE in hepatocellular carcinoma is associated with poor prognosis.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
61 KDa
SMILES Code
NONE
别名
重组人IL-17RE蛋白(C-Fc, HEK293)
;Recombinant Human IL-17RE (C-Fc, HEK293); IL-17 RE; IL-17 receptor E; IL17RE; IL-17RE; interleukin 17 receptor E
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293)
|Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293)
| 重组人IL-17RE蛋白(C-Fc, HEK293)
| Recombinant Human IL-17RE (C-Fc, HEK293)
| IL-17 RE
| IL-17 receptor E
| IL17RE
| IL-17RE
| interleukin 17 receptor E
| N/A
| Cytokines and Growth Factor Receptors
| Epithelial cell CD Proteins
| Endothelial cell CD Proteins
| Interleukin & Receptors
| Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 纯度/质量文件
| Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 生物活性
| Human IL-17RE (C-Fc, HEK293)/人IL-17RE蛋白(C-Fc, HEK293) 技术信息
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