货号:A2900810
同义名:
重组人IL-17D蛋白(E.coli, tag free)
/ Recombinant Human IL-17D; Interleukin-17D
Recombinant Human IL-17D是人源白细胞介素-17D蛋白,在大肠杆菌中表达,为无标签蛋白。该蛋白属于IL-17家族,与IL-17B亲缘关系最近,主要在骨骼肌、心脏、脂肪组织、肺、胰腺及神经系统中表达,是一种促炎细胞因子,可刺激产生IL-6、IL-8和GM-CSF等细胞因子,调节免疫功能,并能抑制髓系祖细胞的增殖。


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| 描述 | The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | Tag free |
| 蛋白表达区间 | Ala18-Pro202 |
| 蛋白编号 | Q8TAD2 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM Glycine-HCl, 4% Sucrose, 4% Mannitol, 0.02% Tween 80, pH3.0. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 20.3 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IL-17D蛋白(E.coli, tag free) ;Recombinant Human IL-17D; Interleukin-17D; IL-17D; IL17D |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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