Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His)
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货号：A2900911同义名：
重组人IL-17C蛋白(HEK293, C-6His)
/ Recombinant Human IL-17C (C-6His); CX2
Recombinant Human IL-17C (C-6His)是人源蛋白，在人源细胞中表达，带有C端6×His标签。该蛋白是一种15-20 kDa糖基化细胞因子，在黏膜免疫和慢性炎症中起重要作用，可结合IL-17RE与IL-17RA受体，参与抗菌肽及促炎因子诱导，与多种慢性炎症疾病如银屑病、COPD相关，能促进肠上皮修复但也加剧关节炎与银屑病病变。
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 化学结构 CAS号：N/A
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 3D分子结构 CAS号：N/A
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 质控信息
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 生物活性
描述
Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL 17C. IL 17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL 17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL 17C with IL 17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL 17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL 17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL 17A, IL 17F, IL 22, CCR6, and CCL20.
Lyophilized from a 0.2 μm filtered solution of 20mM NaAc, 50mM NaCl, 6% Trehalose, 2% Mannitol, 0.05% Tween 80, pH5.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 技术信息
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