Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 质控信息
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 生物活性
描述
产品名称：Recombinant Human IL-17C (C-6His)理论分子量：20.6 KDa蛋白种属：Human表达系统：Human Cells蛋白表达区间：His19-Val197标签：C-6His剂型：干粉纯度：≥90% as determined by reducing SDS-PAGE.储存条件：冻干蛋白应储存在≤-20°C，收到后可稳定保存一年。
溶解后的蛋白溶液可以在2-8°C下保存2-7天。如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。产品背景：Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL 17C. IL 17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL 17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL 17C with IL 17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL 17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL 17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL 17A, IL 17F, IL 22, CCR6, and CCL20.
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 技术信息
CAS号
N/A
分子量
20.6 KDa
SMILES Code
NONE
别名
重组人IL-17C蛋白(HEK293, C-6His)
;Recombinant Human IL-17C (C-6His)
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His)
|Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His)
| 重组人IL-17C蛋白(HEK293, C-6His)
| Recombinant Human IL-17C (C-6His)
| N/A
| Interleukin & Receptors
| Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 纯度/质量文件
| Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 生物活性
| Human IL-17C (C-6His)/人IL-17C蛋白(HEK293, C-6His) 技术信息
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