Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293)
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货号：A2924140同义名：
重组人IL-15RA&IL-15蛋白(C-Fc, HEK293)
/ Recombinant Human IL-15RA&IL-15 (C-Fc, HEK293); IL15RA&IL15
Recombinant Human IL-15RA&IL-15 (C-Fc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该产品包含高亲和力白细胞介素-15受体α（IL15RA）与白细胞介素-15（IL-15），其中IL15RA可与IL-2受体β和γ亚基形成异源三聚体启动信号传导，并能在细胞间顺式或反式传递信号；IL-15与IL-15RAα亚基高亲和力结合，调控T细胞和NK细胞活化增殖，与IL-2功能相关但又有显著区别。
Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293) 质控信息
Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293) 生物活性
描述
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Trehalose, 4% Mannitol, 0.02% Tween80 (w/v), pH 7.5.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-15RA&IL-15 (C-Fc, HEK293)/人IL-15RA&IL-15蛋白(C-Fc, HEK293) 技术信息
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