Recombinant Human IL-12B (HEK293)是人源蛋白，在人源细胞中表达，不带标签。该蛋白为白细胞介素-12β亚基（IL-12B），属于I型细胞因子受体家族，含1个纤连蛋白III型结构域和1个Ig样C2型结构域，与IL-12A共同组成具有生物活性的异二聚体IL-12，可作用于T细胞和NK细胞，促进Th1细胞发育，增强对胞内病原体的长效免疫保护。
Human IL-12B (HEK293)/人IL-12B蛋白(Tag free, HEK293) 化学结构 CAS号：N/A
Human IL-12B (HEK293)/人IL-12B蛋白(Tag free, HEK293) 3D分子结构 CAS号：N/A
Human IL-12B (HEK293)/人IL-12B蛋白(Tag free, HEK293) 质控信息
Human IL-12B (HEK293)/人IL-12B蛋白(Tag free, HEK293) 生物活性
描述
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IL-12B (HEK293)/人IL-12B蛋白(Tag free, HEK293) 技术信息
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