Human IL-12/人IL-12蛋白(HEK293, tag free)
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货号：A2900777同义名：
重组人IL-12蛋白(HEK293, tag free)
/ Recombinant Human IL-12; Interleukin-12 subunit alpha
Recombinant Human IL-12是人源白细胞介素-12，由人源细胞表达，无标签。该蛋白是由40 kDa（p40）和35 kDa（p35）两个亚基组成的异二聚体多效性细胞因子，与人及小鼠的p40和p35亚基分别具有70%和60%的氨基酸序列同源性。Recombinant Human IL-12参与初始T细胞向Th1细胞的分化，可刺激T细胞与自然杀伤细胞的生长与功能，促进干扰素-γ和肿瘤坏死因子-α的产生，增强NK细胞与CD8+ T细胞的细胞毒活性。
Human IL-12/人IL-12蛋白(HEK293, tag free) 化学结构 CAS号：N/A
Human IL-12/人IL-12蛋白(HEK293, tag free) 3D分子结构 CAS号：N/A
IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL‑12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
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