货号:A2924019
同义名:
重组人IL-10RB蛋白(C-Fc, HEK293)
/ Recombinant Human IL-10RB (C-Fc, HEK293); Interleukin-10 receptor subunit beta(IL10RB)
Recombinant Human IL-10RB (C-Fc, HEK293) 是人源重组蛋白,采用人源细胞(HEK293)表达系统表达,带有C-Fc标签。该蛋白为白细胞介素-10受体亚基β(IL10RB),属于II型细胞因子受体家族,是一种单次跨膜I型膜蛋白,含两个纤维连接蛋白III型结构域,是IL10信号通路中不可或缺的辅助链,与IL10RA共表达可介导IL10信号转导,其缺陷会导致炎症性肠病25(IBD25)。


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| 描述 | Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Met20-Ser220 |
| 蛋白编号 | Q08334 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 50.6 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IL-10RB蛋白(C-Fc, HEK293) ;Recombinant Human IL-10RB (C-Fc, HEK293); Interleukin-10 receptor subunit beta(IL10RB); Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Interleukin-10 receptor subunit 2; |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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