货号:A2923990
同义名:
重组人IGFBP-5蛋白(C-6His, HEK293)
/ Recombinant Human IGFBP-5 (C-6His, HEK293); Insulin-Like Growth Factor-Binding Protein 5
Recombinant Human IGFBP-5 (C-6His, HEK293) 是人源胰岛素样生长因子结合蛋白5,在HEK293人源细胞中表达,带有C端6×His标签。该蛋白属于IGF结合蛋白超家族,可延长IGF半衰期并调节其促生长作用,通过与IGF受体相互作用影响信号传导。IGFBP-5含一个N端IGFBP结构域和一个甲状腺球蛋白1型结构域,主要由成纤维细胞、成肌细胞及骨肉瘤细胞表达,也少量存在于肝、肾和脑组织中。


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| 描述 | Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed by fibroblasts, myoblasts and Osteosarcoma. It is also present at lower levels in liver, kidney, and brain. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Leu21-Glu272 |
| 蛋白编号 | P24593 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 29.61 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IGFBP-5蛋白(C-6His, HEK293) ;Recombinant Human IGFBP-5 (C-6His, HEK293); Insulin-Like Growth Factor-Binding Protein 5; IBP-5; IGF-Binding Protein 5; IGFBP-5; IGFBP5; IBP5 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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