/Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293)
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293)
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货号：A2925675同义名：
重组人IGF-I R蛋白(C-6His, HEK293)
/ Recombinant Human IGF-I R (C-6His, HEK293); CD221 antigen
Recombinant Human IGF-I R (C-6His, HEK293) 是人源胰岛素样生长因子-1受体（IGF1R）重组蛋白，在HEK293人源细胞中表达，带有C端6×His标签。该蛋白是由两个α和两个β亚基组成的二硫键连接异源四聚体跨膜蛋白，参与细胞增殖、分化、DNA修复及细胞存活等关键生物过程，是癌症治疗的重要靶点。
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293) 质控信息
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293) 生物活性
描述
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells, is now an attractive anti-cancer treatment target.
Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA, 0.5% Tween-20, 5% Trehalose, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IGF-I R (C-6His, HEK293)/人IGF-I R蛋白(C-6His, HEK293) 技术信息
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