Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 质控信息
Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 生物活性
描述
Interferon α/β Receptor 2 (IFN-α/β R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-α/β R1 to form the signaling receptor complex for the family of α and β IFN subtypes. By alternative splicing, IFN-α/β R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-α/β R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-α/β R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
51.8 KDa
SMILES Code
NONE
别名
重组人IFNAR2蛋白(C-Fc, HEK293)
;Recombinant Human IFNAR2 (C-Fc, HEK293); Interferon Alpha/Beta Receptor 2; IFN-R-2; IFN-Alpha Binding Protein; IFN-Alpha/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFNABR; IFNARB
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293)
|Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293)
| 重组人IFNAR2蛋白(C-Fc, HEK293)
| Recombinant Human IFNAR2 (C-Fc, HEK293)
| Interferon Alpha/Beta Receptor 2
| IFN-R-2
| IFN-Alpha Binding Protein
| IFN-Alpha/Beta Receptor 2
| Interferon Alpha Binding Protein
| Type I Interferon Receptor 2
| IFNAR2
| IFNABR
| IFNARB
| N/A
| Interferon & Receptors
| Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 纯度/质量文件
| Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 生物活性
| Human IFNAR2 (C-Fc, HEK293)/人IFNAR2蛋白(C-Fc, HEK293) 技术信息
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