/Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293)
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293)
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货号：A2926422同义名：
重组人HLA-A*1101 KRAS(G12D)蛋白复合体(C-10His, HEK293)
/ Recombinant Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293); HLA-A*1101 KRAS(G12D) complex Protein
Recombinant Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 是人源蛋白，在HEK293细胞中表达，带有C端10xHis标签。该蛋白为KRAS(G12D)突变体与HLA-A*1101形成的复合物，属于小GTP酶Ras家族，具有GTP/GDP结合及GTP酶活性，参与调控细胞增殖与信号转导，其突变与结直肠癌等多种肿瘤的发生密切相关，该复合物可用于免疫研究及药物开发。
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 化学结构 CAS号：N/A
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 3D分子结构 CAS号：N/A
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 质控信息
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 生物活性
描述
K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 1 个月。
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 技术信息
CAS号
N/A
分子量
50.9 KDa
SMILES Code
NONE
别名
重组人HLA-A*1101 KRAS(G12D)蛋白复合体(C-10His, HEK293)
;Recombinant Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293); HLA-A*1101 KRAS(G12D) complex Protein
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293)
|Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293)
| 重组人HLA-A*1101 KRAS(G12D)蛋白复合体(C-10His, HEK293)
| Recombinant Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293)
| HLA-A*1101 KRAS(G12D) complex Protein
| N/A
| 胰腺肿瘤
| 结直肠肿瘤
| 肺肿瘤
| Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 纯度/质量文件
| Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 生物活性
| Human HLA-A*1101 KRAS(G12D) complex Protein (C-10His, HEK293) 技术信息
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