Recombinant Human GUCY2C (C-Fc, HEK293)是人源GUCY2C蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白又称热稳定肠毒素受体，属于鸟苷酸环化酶家族I型跨膜蛋白，主要表达于肠上皮腔面及部分下丘脑神经元表面，靶向其可避免肠道毒性并用于结直肠癌转移治疗，潜在应用于GUCY2C阳性胃肠道恶性肿瘤的CAR-T疗法。
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 质控信息
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 生物活性
描述
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the intestinal epithelium and a subset of hypothalamic neurons. The inaccessibility of GUCY2C in the apical membranes of polarized epithelial tissue, due to subcellular restriction of GUCY2C, creates a therapeutic opportunity to target metastatic lesions of colorectal origin which have lost apicalbasolateral polarization without concomitant intestinal toxicity. And that CAR-T cells targeting murine GUCY2C were effective against colorectal cancer metastatic to lung in the absence of intestinal toxicities. Human GUCY2C-targeted CAR that could potentially be employed in patients with GUCY2C-expressing gastrointestinal malignancies.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
72.9 KDa
SMILES Code
NONE
别名
重组人GUCY2C蛋白(C-Fc, HEK293)
;Recombinant Human GUCY2C (C-Fc, HEK293); Heat-stable enterotoxin receptor; GUCY2C; STA receptor; hSTAR; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase; GUC2C; STAR
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293)
|Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293)
| 重组人GUCY2C蛋白(C-Fc, HEK293)
| Recombinant Human GUCY2C (C-Fc, HEK293)
| Heat-stable enterotoxin receptor
| GUCY2C
| STA receptor
| hSTAR
| Guanylyl cyclase C
| GC-C
| Intestinal guanylate cyclase
| GUC2C
| STAR
| N/A
| Lyases (EC 4)
| Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 纯度/质量文件
| Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 生物活性
| Human GUCY2C (C-Fc, HEK293)/人GUCY2C蛋白(C-Fc, HEK293) 技术信息
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