货号:A2926475
同义名:
重组人GLP1R N-ECD蛋白(C-6His, HEK293)
/ Recombinant Human GLP1R N-ECD (C-6His, HEK293); Glucagon-like peptide 1 receptor
Recombinant Human GLP1R N-ECD (C-6His, HEK293)是人源蛋白,在HEK293人源细胞中表达,带有C端6×His标签。该产品为胰高血糖素样肽-1受体(GLP-1R)的N端胞外域片段,GLP-1R是B1类G蛋白偶联受体,在代谢调节中发挥重要作用,广泛分布于胰岛、胃、肠、心、肾、肺和脑等组织,其胞外域包含β折叠、二硫键及柔性α螺旋结构,是代谢疾病治疗的重要靶点。


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| 描述 | The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. The GLP-1R is a class B1 G protein-coupled receptor (GPCR) that mediates its effects via coupling to heterotrimeric G proteins. It's typically characterized by a relatively large extracellular domain (ECD) and 7 transmembrane core domains (TMDs) composed of α-helical beams. The extracellular domain (ECD) consists of two sets of reverse β folds connected by loop loops, 3 pairs of disulfide bonds formed by 6 conserved cysteines, and a flexible α helix. And GLP-1R is highly conserved in model organisms and humans, and it is widely distributed in the detected islets, stomach, small intestine, heart, kidney, lung and brain tissues. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Arg24-Glu139 |
| 蛋白编号 | P43220 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 14.4 KDa |
| SMILES Code | NONE |
| 别名 | 重组人GLP1R N-ECD蛋白(C-6His, HEK293) ;Recombinant Human GLP1R N-ECD (C-6His, HEK293); Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; GLP1R |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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