货号:A2925898
同义名:
重组人GLP1蛋白(C-6His, HEK293)
/ Recombinant Human GLP1 (C-6His, HEK293); Glucagon
Recombinant Human GLP1 (C-6His, HEK293) 是人源胰高血糖素家族蛋白,在人源细胞中表达,带有C端6×His标签。该蛋白可被切割成8条链,通过调节糖酵解与糖异生影响血糖水平,参与糖尿病高血糖状态的启动与维持,其释放受低血糖刺激,高血糖、胰岛素及生长抑素抑制。该拮抗型变体缺失His-53和Phe-58,可用于体内降糖研究。


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| 描述 | Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Arg21-Lys180 |
| 蛋白编号 | P01275 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 50% Glycerol, pH 8.0. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 18.6 KDa |
| SMILES Code | NONE |
| 别名 | 重组人GLP1蛋白(C-6His, HEK293) ;Recombinant Human GLP1 (C-6His, HEK293); Glucagon; Glicentin; Glicentin-Related Polypeptide; GRPP; Oxyntomodulin; OXM; OXY; Glucagon; Glucagon-Like Peptide 1; GLP-1; Incretin Hormone; Glucagon-like Peptide 1; GLP-1; Glucagon-Like Peptide 2; GLP-2; GCG |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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