Human GDF15 (N-Fc, HEK293)/人GDF15蛋白(N-Fc, HEK293)
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货号：A2926394同义名：
重组人GDF15蛋白(N-Fc, HEK293)
/ Recombinant Human GDF15 (N-Fc, HEK293); GDF15
Recombinant Human GDF15 (N-Fc, HEK293)是人类GDF15蛋白，在HEK293人源细胞中表达，带有N端Fc标签。该蛋白又称MIC-1、胎盘TGF-β等，是TGF-β超家族成员，成熟形式为二硫键连接的同源二聚体，通过TGF-βRI/ALK-5与TGF-βRII异源二聚体受体传递信号，具有抑制炎症、促进骨与神经发育、调节食欲及心血管保护等多种生物学功能。
Human GDF15 (N-Fc, HEK293)/人GDF15蛋白(N-Fc, HEK293) 化学结构 CAS号：N/A
Human GDF15 (N-Fc, HEK293)/人GDF15蛋白(N-Fc, HEK293) 3D分子结构 CAS号：N/A
Human GDF15 (N-Fc, HEK293)/人GDF15蛋白(N-Fc, HEK293) 质控信息
Human GDF15 (N-Fc, HEK293)/人GDF15蛋白(N-Fc, HEK293) 生物活性
描述
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), Placental Transforming Growth Factor beta, Prostate-derived Factor, and Placental Bone Morphogenetic Protein, is a divergent member of the TGF-beta superfamily. Similar to other TGF-beta family proteins, the GDF-15 proprotein is cleaved at a dibasic cleavage site (RxxR) to release the mature protein. The C-terminal domain of GDF-15 contains seven characteristic conserved cysteine residues necessary for the formation of the cysteine knot and the single interchain disulfide bond. Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein and signals through the heterodimeric receptor composed of TGF-beta RI/ALK-5 and TGF-beta RII. GDF-15 has been shown to have various functions, including inhibition of TNF-alpha production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. GDF-15 also promotes neuronal survival, and hypothalamic expression of GDF-15 causes appetite suppression via modulation of Neuropeptide Y and Pro-opiomelanocortin levels. GDF-15 is cardioprotective via inhibition of platelet activation, limiting atherosclerosis, inhibiting CXCL1-induced neutrophil adhesion, regulating angiogenesis, and inhibiting norepinephrine-induced mycardial hypertrophy.
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