货号:A2900760
同义名:
重组人GDF-11蛋白(HEK293, tag free)
/ Recombinant Human GDF-11; Growth/differentiation factor 11
Recombinant Human/Mouse/Rat GDF-11是人/小鼠/大鼠来源的生长分化因子11,在人源细胞中表达,无标签。该蛋白属于转化生长因子β超家族,是一种分泌型蛋白,可调控Hox基因表达,控制胚胎前后轴的发育模式。GDF-11通过类似肌肉抑制素(myostatin)的信号通路抑制神经发生,能阻止祖细胞在G期进入细胞周期,提示其在肌肉与神经组织大小调控中可能共用相似机制。


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| 描述 | Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development. |
| 蛋白种属 | Human/Mouse/Rat |
| 表达系统 | Human Cells |
| 标签 | Tag free |
| 蛋白表达区间 | Asn299-Ser407 |
| 蛋白编号 | O95390 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 12.5 KDa |
| SMILES Code | NONE |
| MDL No. | N/A |
| 别名 | 重组人GDF-11蛋白(HEK293, tag free) ;Recombinant Human GDF-11; Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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