Recombinant Human G-CSFR (C-Fc, HEK293)是人类粒细胞集落刺激因子受体（G-CSFR，又称CD114）重组蛋白，来自人源细胞HEK293表达系统，带有C端Fc标签。该蛋白是调控粒细胞生成、分化与功能的关键受体，属于细胞因子受体家族，也参与部分细胞黏附或识别过程，其突变与先天性中性粒细胞减少症进展为急性髓系白血病相关，并可能在实体瘤转移中发挥作用。
Human G-CSFR (C-Fc, HEK293)/人G-CSFR蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human G-CSFR (C-Fc, HEK293)/人G-CSFR蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human G-CSFR (C-Fc, HEK293)/人G-CSFR蛋白(C-Fc, HEK293) 质控信息
Human G-CSFR (C-Fc, HEK293)/人G-CSFR蛋白(C-Fc, HEK293) 生物活性
描述
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, the protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human G-CSFR (C-Fc, HEK293)/人G-CSFR蛋白(C-Fc, HEK293) 技术信息
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