Recombinant Human FOLR1 (C-Fc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白为叶酸受体α（FOLR1），主要在上皮组织中表达，也存在于肾脏、肺和小脑中，可结合叶酸及其类似物并介导其进入细胞，具有pH依赖性的叶酸结合与释放特性，对胚胎发育和细胞增殖具有重要作用。
Human FOLR1 (C-Fc, HEK293)/人FOLR1蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human FOLR1 (C-Fc, HEK293)/人FOLR1蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human FOLR1 (C-Fc, HEK293)/人FOLR1蛋白(C-Fc, HEK293) 质控信息
Human FOLR1 (C-Fc, HEK293)/人FOLR1蛋白(C-Fc, HEK293) 生物活性
描述
Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human FOLR1 (C-Fc, HEK293)/人FOLR1蛋白(C-Fc, HEK293) 技术信息
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