Recombinant Human EphA7 (C-6His, HEK293)是人类EphA7蛋白，在HEK293人源细胞中表达，带有C端6×His标签。该蛋白属于Eph家族跨膜受体酪氨酸激酶，具有纤连蛋白III型结构域、激酶结构域和SAM结构域，是ephrin-A家族的受体，参与神经轴突导向及肿瘤发生，与肺癌、肝癌等恶性肿瘤的恶性转化、侵袭和转移密切相关。
Human EphA7 (C-6His, HEK293)/人EphA7蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human EphA7 (C-6His, HEK293)/人EphA7蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human EphA7 (C-6His, HEK293)/人EphA7蛋白(C-6His, HEK293) 质控信息
Human EphA7 (C-6His, HEK293)/人EphA7蛋白(C-6His, HEK293) 生物活性
描述
Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA7 is a receptor for members of the ephrin-A family. Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. EPHA7 functions as a repulsive guidance molecule during the targeting of retinal axons to the superior colliculus and of neocortical axons to the thalamus. EPHA7 is expressed at a substantial level in most human lung cancers. The high expression of EPHA7 protein may participate in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma. EPHA7 may involve in smoking related lung carcinogenesis.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human EphA7 (C-6His, HEK293)/人EphA7蛋白(C-6His, HEK293) 技术信息
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