货号:A2924983
同义名:
重组人EFNA5蛋白(C-Fc, HEK293)
/ Recombinant Human EFNA5 (C-Fc, HEK293); Ephrin-A5
Recombinant Human EFNA5 (C-Fc, HEK293) 是人源 Ephrin-A5 蛋白,在 HEK293 人源细胞中表达,带有 C-Fc 标签。该蛋白属于 ephrin 家族,含有一个 ephrin 受体结合结构域,是 Eph 受体的细胞表面 GPI 锚定配体,参与神经、血管及上皮发育过程中的迁移、排斥与粘附。其通过与 EPHA5 等 Eph 受体相互作用,调控胰岛细胞间通讯及葡萄糖刺激的胰岛素分泌,并在脑发育中调节细胞粘附与排斥。


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| 描述 | Ephrin-A5 (EFNA5) belongs to the ephrin family,contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc |
| 蛋白表达区间 | Gln21-Asn203 |
| 蛋白编号 | P52803 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 48.3 KDa |
| SMILES Code | NONE |
| 别名 | 重组人EFNA5蛋白(C-Fc, HEK293) ;Recombinant Human EFNA5 (C-Fc, HEK293); Ephrin-A5; EPLG7; LERK7; EFNA5; LERK-7; EPH-related receptor tyrosine kinase ligand 7; AL-1 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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