Recombinant Human Dectin-1 (N-Fc, HEK293)是人类Dectin-1蛋白，在HEK293人源细胞中表达，带有N端Fc标签。该蛋白是识别β-葡聚糖的关键受体，属II型跨膜蛋白，可结合β-1,3和β-1,6葡聚糖，主要表达于先天免疫系统细胞，参与真菌的吞噬与杀伤，激活后可诱导有效免疫应答，有助于免疫低下者抵御机会性真菌感染。
Human Dectin-1 (N-Fc, HEK293)/人Dectin-1蛋白(N-Fc, HEK293) 化学结构 CAS号：N/A
Human Dectin-1 (N-Fc, HEK293)/人Dectin-1蛋白(N-Fc, HEK293) 3D分子结构 CAS号：N/A
Human Dectin-1 (N-Fc, HEK293)/人Dectin-1蛋白(N-Fc, HEK293) 质控信息
Human Dectin-1 (N-Fc, HEK293)/人Dectin-1蛋白(N-Fc, HEK293) 生物活性
描述
Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human Dectin-1 (N-Fc, HEK293)/人Dectin-1蛋白(N-Fc, HEK293) 技术信息
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