Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 质控信息
Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 生物活性
描述
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. In mammals, four Notch homologs (Notch 1 to4) and five ligands (DLL 1, 3 and 4, Jagged 1 and 2) have been identified. DLL4 is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch 1 and Notch 4. Human and mouse DLL4 shares 86% amino acid sequence identity. Notch ligands are transmembrane proteins with a DSL motif necessary for Notch binding, tandem EGF repeats, a transmembrane region and a short intracellular domain (ICD). Notch ligands are categorized into two subfamilies based on the presence of an extracellular cysteinerich domain and insertions that interrupt some EGF repeats in the Jagged but not the Delta ligand family. Interactions of Notch receptors with their ligands result in reciprocal regulated intramembrane proteolysis (RIP). RIP is a mechanism for transmembrane signal transduction that involves the sequential processing by a disintegrin metalloprotease (ADAM) and then by presenilin/ γ secretase, resulting in shedding of the extracellular domains and the generation of the soluble ICD signaling fragments, respectively.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 6% Trehalose, 4% Mannitol, 50mM NaCl, 0.05% Tween80, pH8.5.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
81.2 KDa
SMILES Code
NONE
别名
重组人DLL4蛋白(C-Fc, HEK293)
;Recombinant Human DLL4 (C-Fc, HEK293); Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293)
|Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293)
| 重组人DLL4蛋白(C-Fc, HEK293)
| Recombinant Human DLL4 (C-Fc, HEK293)
| Delta-like protein 4
| Drosophila Delta homolog 4
| Delta4
| DLL4
| N/A
| Notch family
| Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 纯度/质量文件
| Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 生物活性
| Human DLL4 (C-Fc, HEK293)/人DLL4蛋白(C-Fc, HEK293) 技术信息
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