Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 质控信息
Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 生物活性
描述
Delta-like protein 1 (DLL1) is a type I transmembrane protein that belongs to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Mature human DLL1 consists of a 528 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain. Within the ECD, human DLL1 shares 91% aa sequence identity with mouse and rat DLL1. The residual membranebound portion of DLL1 can be cleave by presenilin-dependent γ-secretase, enabling the cytoplasmic domain to migrate to the nucleus. DLL1 localizes to adherens junctions on neuronal processes through its association with the scaffolding protein MAGI1. DLL1 is widely expressed, and it plays an important role in embryonic somite formation, cochlear hair cell differentiation, plus B and T lymphocyte differentiation. The upregulation of DLL1 in arterial endothelial cells following injury or angiogenic stimulation is central to postnatal arteriogenesis. DLL1 is also overexpressed in cervical carcinoma and glioma and contributes to tumor progression.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 50mM NaCl, 10% Trehalose, 0.05% Tween80, 2mM EDTA, pH8.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
83.3 KDa
SMILES Code
NONE
别名
重组人DLL1蛋白(C-Fc, HEK293)
;Recombinant Human DLL1 (C-Fc, HEK293); Delta-like protein 1; Drosophila Delta homolog 1; Delta1; H-Delta-1; DLL1
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293)
|Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293)
| 重组人DLL1蛋白(C-Fc, HEK293)
| Recombinant Human DLL1 (C-Fc, HEK293)
| Delta-like protein 1
| Drosophila Delta homolog 1
| Delta1
| H-Delta-1
| DLL1
| N/A
| Notch family
| Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 纯度/质量文件
| Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 生物活性
| Human DLL1 (C-Fc, HEK293)/人DLL1蛋白(C-Fc, HEK293) 技术信息
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