Chemokine Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. It can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CXCL2/人CXCL2蛋白(E.coli, tag free) 技术信息
CAS号
N/A
分子量
7.67 KDa
SMILES Code
NONE
别名
重组人CXCL2蛋白(E.coli, tag free)
;Recombinant Human CXCL2; C-X-C Motif Chemokine 2; Growth-Regulated Protein Beta; Gro-Beta; Macrophage Inflammatory Protein 2-Alpha; MIP2-Alpha; CXCL2; GRO2; GROB; MIP2A; SCYB2
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CXCL2/人CXCL2蛋白(E.coli, tag free)
|Human CXCL2/人CXCL2蛋白(E.coli, tag free)
| 重组人CXCL2蛋白(E.coli, tag free)
| Recombinant Human CXCL2
| C-X-C Motif Chemokine 2
| Growth-Regulated Protein Beta
| Gro-Beta
| Macrophage Inflammatory Protein 2-Alpha
| MIP2-Alpha
| CXCL2
| GRO2
| GROB
| MIP2A
| SCYB2
| N/A
| Chemokine & Receptors
| Human CXCL2/人CXCL2蛋白(E.coli, tag free) 纯度/质量文件
| Human CXCL2/人CXCL2蛋白(E.coli, tag free) 生物活性
| Human CXCL2/人CXCL2蛋白(E.coli, tag free) 技术信息
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