Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293)
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货号：A2925374同义名：
重组人CTLA-4蛋白(C-mFc, HEK293)
/ Recombinant Human CTLA-4 (C-mFc, HEK293); Cytotoxic T-lymphocyte protein 4
Recombinant Human CTLA-4 (C-mFc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有C端mFc标签。该蛋白为细胞毒性T淋巴细胞相关抗原4（CTLA-4，CD152），是一种I型跨膜T细胞抑制分子，属于免疫球蛋白超家族，主要表达于淋巴组织，通过与B7-1/B7-2及CD28相互作用调控T、B细胞应答，发挥重要的免疫抑制功能。
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 化学结构 CAS号：N/A
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 3D分子结构 CAS号：N/A
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 质控信息
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 生物活性
描述
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 技术信息
CAS号
N/A
分子量
40.1 KDa
SMILES Code
NONE
别名
重组人CTLA-4蛋白(C-mFc, HEK293)
;Recombinant Human CTLA-4 (C-mFc, HEK293); Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA4; CD152
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293)
|Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293)
| 重组人CTLA-4蛋白(C-mFc, HEK293)
| Recombinant Human CTLA-4 (C-mFc, HEK293)
| Cytotoxic T-lymphocyte protein 4
| Cytotoxic T-lymphocyte-associated antigen 4
| CTLA4
| CD152
| N/A
| Dendritic Cell CD Proteins
| Macrophage CD Proteins
| Immune Checkpoint Proteins
| T Cell CD Proteins
| Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 纯度/质量文件
| Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 生物活性
| Human CTLA-4 (C-mFc, HEK293)/人CTLA-4蛋白(C-mFc, HEK293) 技术信息
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