货号:A2925741
同义名:
重组人CTGF蛋白(C-6His, HEK293)
/ Recombinant Human CTGF (C-6His, HEK293); Connective tissue growth factor
Recombinant Human CTGF (C-6His, HEK293) 是人源结缔组织生长因子(又称CCN2),在HEK293人源细胞中表达,带有C端6×His标签。该蛋白属于CCN家族分泌型基质细胞蛋白,包含IGF结合域、vWF-C域、TSP-1域及半胱氨酸结肝素结合域,参与细胞粘附、迁移、增殖、分化及细胞外基质生成,在器官发育中起重要作用,也是肺、心、肝、肾等器官纤维化和组织重塑的关键介质。


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| 描述 | Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physiologic conditions. CTGF is pathologically viewed as a central mediator of tissue remodeling and fibrosis of various organs, including the lung, heart, liver, and kidney. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Gln27-Ala349 |
| 蛋白编号 | Q5M8T4 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 36.3 KDa |
| SMILES Code | NONE |
| 别名 | 重组人CTGF蛋白(C-6His, HEK293) ;Recombinant Human CTGF (C-6His, HEK293); Connective tissue growth factor; CTGF |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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