Recombinant Human CPA1 (C-6His, HEK293)是人源蛋白，在HEK293细胞中表达，带有C端6×His标签。该蛋白为羧肽酶A1（CPA1），是一种分泌型胰脏肽酶，源自无活性的前羧肽酶原，包含信号肽、前导区及成熟链，经切割后激活，偏好水解含芳香族或支链脂肪族侧链残基的C末端酰胺或酯键，参与酶原抑制，与胰腺酶原E等功能蛋白存在关联。
Human CPA1 (C-6His, HEK293)/人CPA1蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human CPA1 (C-6His, HEK293)/人CPA1蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human CPA1 (C-6His, HEK293)/人CPA1蛋白(C-6His, HEK293) 质控信息
Human CPA1 (C-6His, HEK293)/人CPA1蛋白(C-6His, HEK293) 生物活性
描述
Carboxypeptidase A1 (CPA1) is secreted as a pancreatic peptidase that comes from the precursor form of inactive procarboxypeptidase. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. It has a free C-terminal carboxyl group, with the preference of residues with aromatic or branched aliphatic side chains. CPA1 cleaves the C-terminal amide or ester bond of peptides and involves in zymogen inhibition. Three different forms of human pancreatic procarboxypeptidase A have been isolated. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E.
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