货号:A2924769
同义名:
重组人CFHR5蛋白(C-6His, HEK293)
/ Recombinant Human CFHR5 (C-6His, HEK293); Complement factor H-related protein 5
Recombinant Human CFHR5 (C-6His, HEK293) 是人源补体因子H相关蛋白5,在人源细胞中表达,带有C端6×His标签。该蛋白是一种含9个Sushi结构域的分泌蛋白,主要由肝脏表达并分泌至血浆,可能参与补体激活与调控。其缺陷与不典型溶血尿毒综合征相关,该病预后较差,易进展为终末期肾病。


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| 描述 | Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | Glu19-Glu569 |
| 蛋白编号 | Q9BXR6 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 63.5 KDa |
| SMILES Code | NONE |
| 别名 | 重组人CFHR5蛋白(C-6His, HEK293) ;Recombinant Human CFHR5 (C-6His, HEK293); Complement factor H-related protein 5; CFHR5; CFHL5; FHR5 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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