货号:A2924314
同义名:
重组人CDKN2C蛋白(N-6His, E.coli)
/ Recombinant Human CDKN2C (N-6His, E.coli); Cyclin-Dependent Kinase 4 Inhibitor C
Recombinant Human CDKN2C (N-6His, E.coli) 是人源CDKN2C蛋白,在大肠杆菌中表达,带有N端6×His标签。该蛋白属于INK4家族,是细胞周期依赖性激酶4抑制剂C,可结合并抑制CDK4/CDK6活性,从而调控细胞生长与增殖,其功能依赖于内源性RB蛋白。主要高表达于骨骼肌、胰腺和心脏,参与精子发生调控及肿瘤抑制。


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| 描述 | Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | N-6His |
| 蛋白表达区间 | Met1-Gln168 |
| 蛋白编号 | P42773 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 20.3 KDa |
| SMILES Code | NONE |
| 别名 | 重组人CDKN2C蛋白(N-6His, E.coli) ;Recombinant Human CDKN2C (N-6His, E.coli); Cyclin-Dependent Kinase 4 Inhibitor C; Cyclin-Dependent Kinase 6 Inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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