货号:A2900712
同义名:
重组人CDK2蛋白(E.coli, N-6His)
/ Recombinant Human CDK2 (N-6His); Cyclin-Dependent Kinase 2
Recombinant Human CDK2 (N-6His)由大肠杆菌表达系统生产,目标基因编码Met1-Leu298,并在N末端带有6His标签。
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描述 | 产品名称:Recombinant Human CDK2 (N-6His)理论分子量:36.1 KDa蛋白种属:Human表达系统:E.coli蛋白表达区间:Met1-Leu298标签:N-6His剂型:液体纯度:≥90% as determined by reducing SDS-PAGE.储存条件:储存温度≤-70°C,收到后可稳定保存6个月。 储存于≤-70°C,开封后在无菌条件下可稳定保存3个月。 开封后请按照用量分装,尽量减少反复冻融次数。产品背景:Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells. |
CAS号 | N/A |
分子量 | 36.1 KDa |
SMILES Code | NONE |
别名 | 重组人CDK2蛋白(E.coli, N-6His) ;Recombinant Human CDK2 (N-6His); Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |