Human CD98 (N-mFc, HEK293)/人CD98蛋白(N-mFc, HEK293)
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货号：A2926279同义名：
重组人CD98蛋白(N-mFc, HEK293)
/ Recombinant Human CD98 (N-mFc, HEK293); 4F2 cell-surface antigen heavy chain
Recombinant Human CD98 (N-mFc, HEK293)是人类CD98重组蛋白，在HEK293人源细胞中表达，带有N端mFc标签。该蛋白是一种多功能糖蛋白，参与氨基酸转运、细胞粘附、扩散及增殖等过程，可通过与CD147相互作用促进整合素功能，激活MAPK通路并参与肿瘤发生、转移及纤维化，同时在T细胞活化中也发挥作用。
Human CD98 (N-mFc, HEK293)/人CD98蛋白(N-mFc, HEK293) 化学结构 CAS号：N/A
Human CD98 (N-mFc, HEK293)/人CD98蛋白(N-mFc, HEK293) 3D分子结构 CAS号：N/A
Human CD98 (N-mFc, HEK293)/人CD98蛋白(N-mFc, HEK293) 质控信息
Human CD98 (N-mFc, HEK293)/人CD98蛋白(N-mFc, HEK293) 生物活性
描述
CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.
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